Publications

Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40.

Messenheimer DJ, Jensen SM, Afentoulis ME, Wegmann KW, Feng Z, Friedman DJ, Gough MJ, Urba WJ, Fox BA.

Clin Cancer Res. 2017 Oct 15;23(20):6165-6177. doi: 10.1158/1078-0432.CCR-16-2677. Epub 2017 Aug 28.

PMID: 28855348

Ubiquitinated Proteins Isolated From Tumor Cells Are Efficient Substrates for Antigen Cross-Presentation.

Yu G, Moudgil T, Cui Z, Mou Y, Wang L, Fox BA, Hu HM.

J Immunother. 2017 Jun;40(5):155-163. doi: 10.1097/CJI.0000000000000165.

PMID: 28368960

Immunoprofiling as a predictor of patient's response to cancer therapy-promises and challenges.

Bethmann D, Feng Z, Fox BA.

Curr Opin Immunol. 2017 Apr;45:60-72. doi: 10.1016/j.coi.2017.01.005. Epub 2017 Feb 20. Review.

PMID: 28222333

The Effect of Superparamagnetic Iron Oxide Nanoparticle Surface Charge on Antigen Cross-Presentation.

Mou Y, Xing Y, Ren H, Cui Z, Zhang Y, Yu G, Urba WJ, Hu Q, Hu H.

Nanoscale Res Lett. 2017 Dec;12(1):52. doi: 10.1186/s11671-017-1828-z. Epub 2017 Jan 19.

PMID: 28102523

Combinational Immunotherapy with Allo-DRibble Vaccines and Anti-OX40 Co-Stimulation Leads to Generation of Cross-Reactive Effector T Cells and Tumor Regression.

Yu G, Li Y, Cui Z, Morris NP, Weinberg AD, Fox BA, Urba WJ, Wang L, Hu HM.

Sci Rep. 2016 Nov 22;6:37558. doi: 10.1038/srep37558.

PMID: 27874054

TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles).

Xing Y, Cao R, Hu HM.

Cell Death Dis. 2016 Aug 4;7(8):e2322. doi: 10.1038/cddis.2016.206.

PMID: 27490927

Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-?B signal pathway.

Zhou M, Wen Z, Cheng F, Ma J, Li W, Ren H, Sheng Y, Dong H, Lu L, Hu HM, Wang LX.

Oncoimmunology. 2016 May 13;5(7):e1180485. doi: 10.1080/2162402X.2016.1180485. eCollection 2016 Jul.

PMID: 27622036

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, et al.,

Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. No abstract available. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. 

PMID: 26799652

Glimpse into the future: harnessing autophagy to promote anti-tumor immunity with the DRibbles vaccine.

Page DB, Hulett TW, Hilton TL, Hu HM, Urba WJ, Fox BA.

J Immunother Cancer. 2016 May 17;4:25. doi: 10.1186/s40425-016-0130-4. eCollection 2016. Review.

PMID: 27190627

Ubiquitinated proteins enriched from tumor cells by a ubiquitin binding protein Vx3(A7) as a potent cancer vaccine.

Aldarouish M, Wang H, Zhou M, Hu HM, Wang LX.

J Exp Clin Cancer Res. 2015 Apr 16;34:34. doi: 10.1186/s13046-015-0156-3.

PMID: 25886865

Macrophages enhance tumor-derived autophagosomes (DRibbles)-induced B cells activation by TLR4/MyD88 and CD40/CD40L.

Zhou M, Li W, Wen Z, Sheng Y, Ren H, Dong H, Cao M, Hu HM, Wang LX.

Exp Cell Res. 2015 Feb 15;331(2):320-30. doi: 10.1016/j.yexcr.2014.10.015. Epub 2014 Oct 24.

PMID: 25447440

Consensus guidelines for the detection of immunogenic cell death.

Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, Apetoh L, Aranda F, Barnaba V, Bloy N, Bracci L, Breckpot K, Brough D, Buqué A, Castro MG, Cirone M, Colombo MI, Cremer I, Demaria S, Dini L, Eliopoulos AG, Faggioni A, Formenti SC, Fu?íková J, Gabriele L, Gaipl US, Galon J, Garg A, Ghiringhelli F, Giese NA, Guo ZS, Hemminki A, Herrmann M, Hodge JW, Holdenrieder S, Honeychurch J, Hu HM, Huang X, Illidge TM, Kono K, Korbelik M, Krysko DV, Loi S, Lowenstein PR, Lugli E, Ma Y, Madeo F, Manfredi AA, Martins I, Mavilio D, Menger L, Merendino N, Michaud M, Mignot G, Mossman KL, Multhoff G, Oehler R, Palombo F, Panaretakis T, Pol J, Proietti E, Ricci JE, Riganti C, Rovere-Querini P, Rubartelli A, Sistigu A, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Sukkurwala AQ, Tartour E, Thorburn A, Thorne SH, Vandenabeele P, Velotti F, Workenhe ST, Yang H, Zong WX, Zitvogel L, Kroemer G, Galluzzi L.

Oncoimmunology. 2014 Dec 13;3(9):e955691. eCollection 2014 Oct. Review.

PMID: 25941621

An autophagosome-based therapeutic vaccine for HBV infection: a preclinical evaluation.

Xue M, Fan F, Ding L, Liu J, Su S, Yin P, Cao M, Zhao W, Hu HM, Wang L.

J Transl Med. 2014 Dec 20;12:361. doi: 10.1186/s12967-014-0361-4.

PMID: 25526800

Preliminary analysis of immune responses in patients enrolled in a Phase II trial of cyclophosphamide with allogenic dribble vaccine alone (DPV-001) or with GM-CSF or imiquimod for adjuvant treatment of stage IIIa or IIIb NSCLC

Rachel Sanborn, Brian Boulmay, Rui Li, Bradley Spieler, Kyle Happel, Christopher Paustian, Tarsem Mougdil, Zipei Feng, Christopher Dubay, Brenda Fisher, Yoshinobu Koguchi, Sandra Aung, Eileen Mederos, Carlo Bifulco, Michael McNamara, Keith S Bahjat, William Redmond, Augusto C Ochoa, Hong Ming Hu, Bernard Fox, Walter Urba and Traci Hilton

Journal of ImmunoTherapy of Cancer, Vol 3, Suppl 2, November 4, 2015

Adoptive TIL in HPV-negative oral scca

Rom Leidner, Brendan D Curti, Roxanne M Payne, Walter Urba, Keith S Bahjat, Yoshinobu Koguchi, Krista Nelson, Jennifer A Moore, Marka Crittenden, Yedeh Ying, Ashish Patel, Allen Cheng, Tuan G Bui, Traci Hilton, Christopher Paustian, Sachin Puri, Hong Ming Hu, Carlo Bifulco, Zipei Feng, R Bryan Bell and Bernard Fox

Journal for ImmunoTherapy of Cancer, Vol 3, Suppl 2, November 4, 2015

Cross-presentation of viral antigens in DRibbles leads to efficient activation of virus-specific human memory T cells

Ye W, Xing Y, Paustian C, van de Ven R, Moudgil T, Hilton TL, Fox BA, Urba WJ, Zhao W, and Hu HM

Journal of Translational Medicine, April 16, 2014

Autophagy-assisted antigen cross-presentation

Yongxiang Yi, Zhenxian Zhou, Su Shu, Yuan Fang, Chris Twitty, Traci L. Hilton, Sandra Aung, Walter J. Urba, Bernard A. Fox, Hong-Ming Hu, and Yuhuan Li

OncoImmunology, September 1, 2012

Tumor-Derived Autophagosome Vaccine: Mechanism of Cross-Presentation and Therapeutic Efficacy

Yuhuan Li, Li-Xin Wang, Puiyi Pang, Zhihua Cui, Sandra Aung, Daniel Haley, Bernard A. Fox, Walter J. Urba, and Hong-Ming Hu

Clinical Cancer Research, November 15, 2011

Tumor-Derived Autophagosome Vaccine: Induction of Cross-Protective Immune Responses against Short-lived Proteins through a p62-Dependent Mechanism

Christopher G. Twitty, Shawn M. Jensen, Hong-Ming Hu, and Bernard A. Fox

Clinical Cancer Research, October 15, 2011

Cross-presentation of tumor associated antigens through tumor-derived autophagosomes

Yuhuan Li, Li-xin Wang, Puiyi Pang, Chris Twitty, Bernard A. Fox, Sandra Aung, Walter J. Urba, and Hong-Ming Hu

Autophagy, May 6, 2009

Efficient Cross-presentation Depends on Autophagy in Tumor Cells

Yuhuan Li, Li-Xin Wang, Guojun Yang, Fang Hao, Walter J. Urba, and Hong-Ming Hu

Cancer Research, September 1, 2008